Which of the following substances requires a separate DEA registration for each practice location?

The requirement for a separate DEA registration for each practice location pertains specifically to controlled substances. Controlled substances are drugs that are regulated by the federal government due to their potential for abuse and dependence. The Drug Enforcement Administration (DEA) mandates that any facility involved in the handling, storage, or dispensing of controlled substances must have its own registration, ensuring that each location is compliant with federal regulations regarding the handling of these substances.

Since controlled substances include a variety of medications that can range from prescription painkillers to sedatives, having a separate registration for each practice location helps maintain accountability and allows for better regulatory oversight. This regulation is essential for preventing misuse and ensuring that controlled substances are managed properly in different practice settings.

On the other hand, over-the-counter medications, herbal supplements, and non-controlled drugs do not have the same strict regulatory requirements concerning DEA registration. These substances are either not subject to DEA regulation or are managed under different guidelines where a separate registration is not necessary for each practice location. Therefore, focusing on controlled substances is crucial for understanding the need for separate registrations under the DEA.